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Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy
Maryann E Mikucki1, Joseph J Skitzki2, John G Frelinger3
1Department of Immunology, Roswell Park Cancer Institute , Buffalo, NY, USA.
Abstract:
Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8(+) T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.
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