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Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity

Roman Uzhachenko1, Anil Shanker2

  • 1Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College , Nashville, TN USA.

Oncoimmunology
|July 29, 2016
PubMed

Notch signaling is crucial for lymphocyte effector and memory differentiation. While tumor suppress Notch signaling in antitumor lymphocytes, recent studies show that the pharmacological Delta-like ligand-1 multivalent cluster or proteasome inhibitor bortezomib can restore Notch-NF-κB signaling in T cells of tumor-bearing hosts with a potential to overcome cancer cell resistance to therapy.

Keywords:
Adoptive T cell therapyDelta-like ligandsNotch signalingantitumor immunitybortezomibcancer immunotherapyimmunosuppression

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