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Harnessing the IL-7/IL-7Rα axis to improve tumor immunotherapy
C Bryce Johnson1, John Wrangle2, Shikhar Mehrotra1
1Department of Surgery, Medical University of South Carolina , Charleston, SC.
Abstract:
IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7Rα, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7Rα and rely on IL-7 for persistence and antitumor immunity.
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