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Updated: Mar 17, 2026

Real-time Iontophoresis with Tetramethylammonium to Quantify Volume Fraction and Tortuosity of Brain Extracellular Space
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CT enterography: Mannitol versus VoLumen.

Jessica Wong1, Helen Moore2, Mark Roger3

  • 1Department of Radiology, Auckland City Hospital, Auckland, New Zealand. jessmariewong@gmail.com.

Journal of Medical Imaging and Radiation Oncology
|July 30, 2016
PubMed
Summary
This summary is machine-generated.

Mannitol demonstrates superior bowel wall visibility and overall study quality in CT enterography (CTE) compared to VoLumen. This makes Mannitol a preferred neutral oral contrast agent for enhanced CTE examinations.

Keywords:
CT enterographyMannitolVoLumenneutral oral contrastsmall bowel

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Area of Science:

  • Radiology
  • Medical Imaging
  • Gastroenterology

Background:

  • Neutral oral contrast agents are crucial for CT enterography (CTE).
  • Mannitol 2.5% and VoLumen are commonly used in Auckland for CTE.
  • Comparative performance data for these agents are limited.

Purpose of the Study:

  • To compare the efficacy of Mannitol 2.5% and VoLumen as neutral oral contrast agents in CTE.
  • To evaluate image quality parameters and patient tolerability.

Main Methods:

  • Retrospective analysis of 25 CTE studies (Mannitol vs. VoLumen).
  • Radiologist assessment of bowel distension, wall visibility, and image quality.
  • Patient questionnaire on contrast agent tolerability.

Main Results:

  • Mannitol significantly improved bowel wall visibility across multiple quadrants (P < 0.01).
  • Overall study quality was superior with Mannitol (48% excellent vs. 4% for VoLumen, P < 0.01).
  • No significant difference was observed in maximal distension or proportion of distended loops.

Conclusions:

  • Mannitol is a viable and effective alternative to VoLumen for CTE.
  • Mannitol enhances diagnostic image quality in CT enterography.