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Updated: Mar 17, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
New potential biomarkers of acetaminophen-induced hepatotoxicity
Katarzyna Siemionow1, Joanna Teul1, Paweł Drągowski1
1Department of Pharmaceutical Analysis, Medical University of Bialystok, Bialystok, Poland.
Abstract:
Acetaminophen (APAP) is one of the most common antipyretic and analgesic drugs. Despite various precautions patients use APAP in amounts exceeding acceptable daily doses. APAP overdosing contributes to APAP intoxication, which leads to acute liver injury or necessity of exigent liver transplantation. Biomarkers that can be helpful in early diagnosis of liver injury during APAP overdosing are studied worldwide. This review presents recent reports on new potential biomarkers and their prospective application in clinical practice.
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