Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

13.5K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
13.5K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

7.3K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
7.3K
Sanger Sequencing01:57

Sanger Sequencing

777.3K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
777.3K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

7.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
7.2K
Mismatch Repair01:36

Mismatch Repair

44.6K
Overview
44.6K
Next-generation Sequencing03:00

Next-generation Sequencing

100.6K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
100.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pattern matching with Elastic-Degenerate strings and Elastic-Founder graphs.

Algorithms for molecular biology : AMB·2026
Same author

<math></math> : indexing maximal common subsequences for k strings.

Algorithms for molecular biology : AMB·2025
Same author

Missing value replacement in strings and applications.

Data mining and knowledge discovery·2025
Same author

RettDb: the Rett syndrome omics database to navigate the Rett syndrome genomic landscape.

Database : the journal of biological databases and curation·2024
Same author

Pangenome comparison via ED strings.

Frontiers in bioinformatics·2024
Same author

Seedability: optimizing alignment parameters for sensitive sequence comparison.

Bioinformatics advances·2023
Same journal

Haplotype-aware long-read error correction.

Algorithms for molecular biology : AMB·2026
Same journal

Extension of partial atom-to-atom maps: uniqueness and algorithms.

Algorithms for molecular biology : AMB·2026
Same journal

Lossless pangenome indexing using tag arrays.

Algorithms for molecular biology : AMB·2026
Same journal

Dolphyin: a combinatorial algorithm for identifying 1-Dollo phylogenies in cancer.

Algorithms for molecular biology : AMB·2026
Same journal

Probing transcription factor subsets in gene regulatory networks.

Algorithms for molecular biology : AMB·2026
Same journal

Comparing the ability of embedding methods on metabolic hypergraphs for capturing taxonomy-based features.

Algorithms for molecular biology : AMB·2026
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.1K

Erratum to: Circular sequence comparison: algorithms and applications.

Roberto Grossi1, Costas S Iliopoulos2, Robert Mercas3

  • 1Department of Informatics, University of Pisa, Pisa, Italy ; ERABLE team, INRA, Paris, France.

Algorithms for Molecular Biology : AMB
|July 30, 2016
PubMed
Summary
This summary is machine-generated.

This study corrects a previous article DOI. The correction ensures accurate citation and retrieval of scientific research, improving data integrity in the field.

More Related Videos

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.7K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.9K

Related Experiment Videos

Last Updated: Mar 17, 2026

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
10:27

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

2.1K
Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.7K
Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.9K

Area of Science:

  • Bibliometrics
  • Scientific Publishing

Context:

  • Accurate citation is crucial for scientific integrity.
  • Digital Object Identifiers (DOIs) are essential for research retrieval.

Purpose:

  • To correct an erroneous Digital Object Identifier (DOI) for a published article.
  • To ensure proper referencing and accessibility of scientific literature.

Summary:

  • A correction has been issued for the DOI of a specific scientific publication.
  • This ensures the article can be accurately located and cited by researchers.

Impact:

  • Enhances the reliability of scientific record-keeping.
  • Facilitates seamless access to published research findings.