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Predictive immune markers in advanced melanoma patients treated with ipilimumab
Viktor Umansky1, Jochen Utikal1, Christoffer Gebhardt1
1Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Heidelberg, Germany.
Oncoimmunology
|July 30, 2016
Abstract:
Myeloid-derived suppressor cells (MDSCs) and chronic inflammatory factors induce immunosuppression and disease progression in advanced melanoma patients. They could serve as important markers allowing the identification of patients with high risk of melanoma progression as well as the detection of those patients who may benefit from the therapy with ipilimumab.
Keywords:
EosinophilsHMGB1S100A8/A9ipilimumabmelanomamyeloid-derived suppressor cellspredictive markers
