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Evaluating Polypoidal Choroidal Vasculopathy With Optical Coherence Tomography Angiography.

Min Wang1, Yao Zhou2, Simon S Gao3

  • 1Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.

Investigative Ophthalmology & Visual Science
|July 30, 2016
PubMed
Summary

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Optical coherence tomography angiography (OCTA) effectively visualizes polypoidal choroidal vasculopathy (PCV) by clearly showing branching vascular networks (BVN) and polypoidal lesions, aiding in understanding PCV pathology.

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Polypoidal choroidal vasculopathy (PCV) is a subtype of neovascular age-related macular degeneration.
  • Accurate imaging is crucial for diagnosing and understanding PCV's unique vascular abnormalities.

Purpose of the Study:

  • To analyze the morphologic characteristics of polypoidal lesions and abnormal branching vascular networks (BVN) in PCV using optical coherence tomography angiography (OCTA).
  • To compare OCTA findings with indocyanine green angiography (ICGA).

Main Methods:

  • Retrospective observational case series of 13 eyes with PCV.
  • Imaging performed using spectral-domain OCT with split-spectrum amplitude-decorrelation angiography (SSADA).
  • Semiautomated segmentation used for detailed analysis of lesions and BVN.

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Main Results:

  • OCTA detected BVN in all cases, located between the retinal pigment epithelium (RPE) and Bruch's membrane.
  • En face OCTA provided clearer visualization of BVN patterns compared to ICGA.
  • Polypoidal lesions showed variable high-flow patterns in the outer retina, typically below the pigment epithelial detachment (PED).

Conclusions:

  • OCTA is a valuable noninvasive tool for visualizing vascular changes in PCV.
  • OCTA offers superior visualization of BVN compared to ICGA.
  • Understanding OCTA patterns of polypoidal lesions and BVN enhances comprehension of PCV pathology.