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Obstructive sleep apnoea in patients with epilepsy: a meta-analysis
Zhang Lin1, Qi Si2, Zou Xiaoyi3
1Department of Neurology, West China Hospital, Sichuan University, Chengdu, 610041, China.
Sleep & Breathing = Schlaf & Atmung
|July 31, 2016
Summary
Obstructive sleep apnoea (OSA) affects over a third of epilepsy patients, a significantly higher rate than the general population. Treating OSA with continuous positive airway pressure (CPAP) therapy may improve seizure control.
Area of Science:
- Neurology
- Sleep Medicine
- Pulmonology
Background:
- Obstructive sleep apnoea (OSA) is a common condition.
- Patients with epilepsy (PWE) may have a higher prevalence of OSA.
- The impact of OSA on seizure control in PWE requires further investigation.
Purpose of the Study:
- To accurately determine the prevalence of OSA in patients with epilepsy (PWE).
- To evaluate the efficacy of treating OSA on seizure control in PWE.
Main Methods:
- Systematic literature search of MEDLINE and Embase databases.
- Data extraction and analysis using random-effects model and odds ratio (OR).
- Prevalence calculated using Apnoea/hypopnoea index (AHI) or respiratory disturbance index (RDI).
Main Results:
- The prevalence of mild-to-severe OSA in PWE is 33.4%.
- PWE are more susceptible to OSA than healthy individuals (OR 2.36).
- Continuous positive airway pressure (CPAP) treatment was associated with better seizure control (OR 5.26).
Conclusions:
- The prevalence of OSA is higher in PWE compared to the general population.
- CPAP treatment for OSA may lead to a reduction in seizures for PWE.
