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An Injectable Magneto-Responsive Periosteum Reprograms Neutrophil Extracellular Trap Formation for Osteomyelitis
Yifan Wu1,2,3,4, Zhang Lin5,6, Jinfeng Zhou1,2,3,4
1Department of Orthopaedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China.
Advanced Materials (Deerfield Beach, Fla.)
|July 21, 2026
Summary
This study introduces a novel biomimetic periosteum hydrogel that, when activated by a magnetic field, effectively combats methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis by triggering an immune response and promoting bone repair.
Area of Science:
- Biomaterials Science
- Immunology
- Nanotechnology
Background:
- Osteomyelitis caused by MRSA biofilms presents treatment challenges due to antibiotic resistance.
- Existing treatments struggle with persistent bacterial presence and bone defect repair.
Purpose of the Study:
- To develop an injectable biomimetic periosteum hydrogel for synergistic MRSA osteomyelitis treatment.
- To investigate the hydrogel's ability to activate innate immunity and promote bone healing.
Main Methods:
- Fabrication of a hydrogel loaded with NiSr MOF@Mem nanocomposites via thiol-click chemistry.
- In vitro and in vivo studies using MRSA models and a rat osteomyelitis model.
- Magnetic field activation to induce ROS bursts, NET formation, and controlled drug release.
Main Results:
- The biomimetic periosteum successfully induced ROS bursts and NET formation via the ROS/PAD4 axis under magnetic field activation.
- The system demonstrated potent synergistic antibacterial effects against planktonic and biofilm MRSA.
- In vivo, the treatment significantly reduced bacterial load and promoted bone repair by modulating the immune microenvironment.
Conclusions:
- The magnetically responsive biomimetic periosteum offers a novel strategy for remotely regulating innate immunity to eradicate MRSA biofilms.
- This integrated approach provides a promising solution for synergistic osteomyelitis treatment and bone regeneration.