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Release studies of trans-anethole from β-cyclodextrin solid inclusion complexes by Multiple Headspace Extraction.

Miriana Kfoury1, Lizette Auezova2, Hélène Greige-Gerges2

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Summary

The preparation method significantly impacts aroma release from beta-cyclodextrin (β-CD) inclusion complexes (IC). Higher temperatures and humidity accelerate aroma release, with co-precipitation coupled to freeze-drying (Cop-FD) showing superior retention.

Keywords:
Controlled releaseInclusion complexesMultiple headspace extractionRelative humidityTemperatureβ-Cyclodextrin

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Area of Science:

  • Food Science and Technology
  • Materials Science
  • Physical Chemistry

Background:

  • Beta-cyclodextrin (β-CD) is widely used for encapsulating active compounds.
  • Controlling aroma release from solid inclusion complexes (IC) is crucial for product stability and sensory experience.
  • Understanding the influence of environmental factors on aroma release is essential for optimizing formulation and storage.

Purpose of the Study:

  • To evaluate the impact of preparation methods (freeze-drying and co-precipitation coupled to freeze-drying) on β-CD/trans-anethole (β-CD/AN) inclusion complex (IC) properties.
  • To investigate the effect of temperature and relative humidity (RH) on the release kinetics of trans-anethole (AN) from β-CD/AN IC.
  • To determine the optimal conditions for retaining aroma within the IC structure.

Main Methods:

  • Preparation of β-CD/AN IC using freeze-drying (FD) and co-precipitation coupled to FD (Cop-FD).
  • Multiple headspace extraction-gas chromatography (MHE) for quantifying loading capacity (LC) and encapsulation efficiency (EE%).
  • Controlled release studies at various temperatures and RH levels, analyzing release kinetics with Avrami's equation.

Main Results:

  • Quantification of encapsulated AN by MHE necessitates IC dissolution.
  • Trans-anethole (AN) release rate significantly increases with higher RH and temperature.
  • AN release was minimal below 75% RH.
  • Cop-FD method demonstrated superior AN retention compared to FD.
  • Avrami's equation effectively modeled the AN release behavior.

Conclusions:

  • The preparation method is a critical factor influencing aroma retention and release from β-CD IC.
  • Environmental conditions (temperature and RH) directly affect the rate of aroma release.
  • The Cop-FD method offers enhanced stability for AN encapsulation.
  • Selection of the preparation method should be tailored to specific application requirements for aroma control.