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Related Experiment Videos

Effect of influenza A on phagocytic cell function.

M Ertürk1, R Jennings, K M Oxley

  • 1Department of Virology, Medical School, University of Sheffield, UK.

Medical Microbiology and Immunology
|January 1, 1989
PubMed
Summary

Influenza virus strains impair polymorphonuclear leucocyte (PMNL) function, reducing bacterial killing capacity. This impairment is linked to haemagglutination activity, not neuraminidase, suggesting NA doesn't primarily cause PMNL dysfunction.

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Area of Science:

  • Immunology
  • Virology

Background:

  • Influenza viruses are significant human pathogens.
  • Polymorphonuclear leucocytes (PMNLs) are critical immune cells for fighting bacterial infections.

Purpose of the Study:

  • To investigate the impact of different influenza virus strains on PMNL function.
  • To determine the role of viral haemagglutination (HA) and neuraminidase (NA) activities in PMNL impairment.

Main Methods:

  • Chemiluminescence (CL) assays were used to measure PMNL activation.
  • Bacterial killing assays assessed PMNL's capacity to eliminate pathogens.
  • Viral HA and NA activities were quantified and correlated with PMNL function.

Main Results:

  • All tested influenza virus strains induced PMNL CL, correlating with HA activity.

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  • Exposure to viruses reduced PMNL's ability to generate CL and kill bacteria.
  • Viral NA activity did not correlate with the degree of PMNL functional impairment.

    • Conclusions:

    • Influenza virus impairs PMNL function, affecting both activation and bactericidal capacity.
    • Haemagglutination activity, not neuraminidase, is associated with virus-induced PMNL dysfunction.
    • Neuraminidase does not appear to be the primary viral factor responsible for impairing PMNL function.