Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimization of flow-focusing devices for homogeneous extensional flow.

Biomicrofluidics·2018
Same author

Purely elastic flow instabilities in microscale cross-slot devices.

Soft matter·2015
Same author

Extensional flow of hyaluronic acid solutions in an optimized microfluidic cross-slot device.

Biomicrofluidics·2014
Same author

Human red blood cell behavior under homogeneous extensional flow in a hyperbolic-shaped microchannel.

Biomicrofluidics·2014
Same author

Shear viscosity and nonlinear behavior of whole blood under large amplitude oscillatory shear.

Biorheology·2014
Same author

Extensional flow of blood analog solutions in microfluidic devices.

Biomicrofluidics·2011
Same journal

Parallelized contactless microfluidic dispenser with superhydrophobic nozzles for scalable combinatorial screening.

Biomicrofluidics·2026
Same journal

Time resolved luminescence of millisecond lifetime dyes in droplet microfluidic systems.

Biomicrofluidics·2026
Same journal

Emerging trends in functional molecularly imprinted polymers for electrochemical detection of biomarkers.

Biomicrofluidics·2025
Same journal

Deep learning assisted mechanotyping of individual cells through repeated deformations and relaxations in undulating channels.

Biomicrofluidics·2025
Same journal

<i>Giardia</i> purification from fecal samples using rigid spiral inertial microfluidics.

Biomicrofluidics·2025
Same journal

Point of care sepsis diagnosis: Exploring microfluidic techniques for sample preparation, biomarker isolation, and detection.

Biomicrofluidics·2025
See all related articles

Related Experiment Video

Updated: Mar 17, 2026

Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls
10:39

Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls

Published on: April 12, 2018

7.8K

Microfluidic converging/diverging channels optimised for homogeneous extensional deformation.

K Zografos1, F Pimenta2, M A Alves2

  • 1James Weir Fluids Laboratory, Department of Mechanical and Aerospace Engineering, University of Strathclyde , Glasgow G1 1XJ, United Kingdom.

Biomicrofluidics
|August 2, 2016
PubMed
Summary
This summary is machine-generated.

This study optimizes microfluidic chip designs to create consistent, homogeneous extensional flow. This advancement is crucial for accurately studying fluid behavior in micro-scale applications.

More Related Videos

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

9.3K
Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

28.1K

Related Experiment Videos

Last Updated: Mar 17, 2026

Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls
10:39

Reconfigurable Microfluidic Channel with Pin-discretized Sidewalls

Published on: April 12, 2018

7.8K
Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape
07:38

Microfluidic Fabrication of Polymeric and Biohybrid Fibers with Predesigned Size and Shape

Published on: January 8, 2014

9.3K
Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow
09:45

Separating Beads and Cells in Multi-channel Microfluidic Devices Using Dielectrophoresis and Laminar Flow

Published on: February 4, 2011

28.1K

Area of Science:

  • Fluid Dynamics
  • Microfluidics
  • Rheology

Background:

  • Homogeneous extensional flow is critical for studying fluid dynamics.
  • Microfluidic devices offer precise control over fluid behavior.
  • Optimizing geometries is key to achieving desired flow conditions.

Purpose of the Study:

  • To optimize microfluidic converging/diverging geometries for constant strain-rates.
  • To enable studies of homogeneous extensional flow in microfluidics.
  • To investigate the applicability of these designs for various flow conditions.

Main Methods:

  • Computational fluid dynamics (CFD) simulations.
  • Optimization of 2D and 3D microfluidic geometries.
  • Analysis of Newtonian, viscoelastic, and electro-osmotic flows.

Main Results:

  • Achieved constant strain-rates along the centerline for homogeneous extension.
  • Investigated effects of aspect ratio and contraction length.
  • Determined limitations for Newtonian (Reynolds number) and viscoelastic (Weissenberg number) flows.
  • Demonstrated applicability for electro-osmotic flows with plug-like velocity profiles.

Conclusions:

  • Optimized microfluidic geometries successfully generate homogeneous extensional flow.
  • The design is versatile, applicable to various fluid types and flow conditions.
  • This work provides a robust platform for microfluidic rheological studies.