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Updated: Mar 17, 2026

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
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Maxillofacial Changes in Melnick-Needles Syndrome.

Leilane Larissa Albuquerque do Nascimento1, Monica da Consolação Canuto Salgueiro2, Mariana Quintela1

  • 1Brazilian Association of Dentistry, 57037-240 Maceió, AL, Brazil.

Case Reports in Dentistry
|August 2, 2016
PubMed
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Melnick-Needles Syndrome, a rare skeletal dysplasia from FLNA gene mutations, causes significant facial and dental abnormalities. Early dental awareness is crucial for managing this condition affecting the stomatognathic system.

Area of Science:

  • Genetics
  • Skeletal Dysplasias
  • Craniofacial Development

Background:

  • Melnick-Needles Syndrome (MNS) is a rare congenital skeletal dysplasia.
  • It stems from mutations in the FLNA gene, encoding filamin A.
  • MNS leads to severe skeletal abnormalities, notably affecting the stomatognathic region.

Purpose of the Study:

  • To present a case of Melnick-Needles Syndrome in a 13-year-old female.
  • To detail the specific skeletal dysplasias observed.
  • To highlight the implications for dental professionals.

Main Methods:

  • Clinical case presentation.
  • Detailed description of skeletal anomalies.
  • Review of syndrome's impact on the stomatognathic system.

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Main Results:

  • The patient exhibited cranial hyperostosis, limb and bone deformities, genu valgum, and spinal issues.
  • Significant micrognathia, hypoplastic mandibular coronoid processes, and potential stylohyoid ligament ossification were noted.
  • Dental development anomalies were also present.

Conclusions:

  • Melnick-Needles Syndrome presents with diverse and severe skeletal abnormalities.
  • The stomatognathic system is profoundly affected, impacting facial development.
  • Dentists must be aware of MNS to address functional and esthetic impairments.