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Photobiomodulation for postoperative pain relief following conventional periapical surgery: a randomised controlled
Rolf Wilhem Consolandich Cirisola1,2, Luis Eduardo Pascuali Moya1,2, María Victoria García Olazabal1,2
1Postgraduate Program in Biophotonics-Medicine, Universidade Nove de Julho (UNINOVE), Sao Paulo, Brazil.
BMJ Open
|November 11, 2025
Summary
This study investigates photobiomodulation (PBM) for managing postoperative pain after periapical surgery. PBM may offer a novel approach to reduce pain and improve recovery following dental procedures.
Area of Science:
- Dentistry
- Pain Management
- Biophotonics
Background:
- Postoperative pain management after periapical surgery requires effective strategies.
- Photobiomodulation (PBM) shows potential for pain relief, but evidence is limited.
- This study addresses the need for more data on PBM's efficacy in this context.
Purpose of the Study:
- To evaluate the effect of photobiomodulation (PBM) on postoperative pain 24 hours after periapical surgery.
- To assess secondary outcomes including pain, swelling, and healing over 7 days and 3 months.
Main Methods:
- A randomized, double-blind, placebo-controlled trial involving 34 patients undergoing periapical surgery.
- Patients received either PBM with placebo ibuprofen or simulated PBM with active ibuprofen.
- Pain was assessed using the Visual Analogue Scale at 24 hours, with further assessments at 7 days and 3 months.
Main Results:
- Primary outcome: postoperative pain at 24 hours (Visual Analogue Scale).
- Secondary outcomes: pain at 7 days, analgesic intake, edema, ecchymosis, soft tissue status, and temperature.
- Radiographic evaluation of healing at 1 and 3 months.
Conclusions:
- The study aims to provide robust evidence on PBM's effectiveness in managing postoperative pain.
- Findings will inform clinical practice regarding PBM as an adjunct therapy for periapical surgery recovery.
- Results will be disseminated to patients, healthcare professionals, and the scientific community.
