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Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
Published on: February 4, 2018
Texas Occurrence of Lyme Disease and Its Neurological Manifestations
Jad A Dandashi1, Damir Nizamutdinov2, Samantha Dayawansa2
1Texas A&M Health Science Center College of Medicine, Temple, Texas, USA.
Abstract:
Today, Lyme disease is the most commonly reported tick-borne disease in the United States and Europe. The culprits behind Lyme disease are the Borrelia species of bacteria. In the USA, Borrelia burgdorferi causes the majority of cases, while in Europe and Asia Borrelia afzelii and Borrelia garinii carry the greatest burden of disease. The clinical manifestations of Lyme disease have been identified as early localized, early disseminated, and late chronic. The neurological effects of Lyme disease include both peripheral and central nervous systems involvement, including focal nerve abnormalities, cranial neuropathies, painful radiculoneuritis, meningitis, and/or toxic metabolic encephalopathy, known as Lyme encephalopathy. Given the geographic predominance of Lyme disease in the Northeast and Midwest of the USA, no major studies have been conducted regarding Southern states. Between 2005 and 2014, the Center for Disease Control has reported 582 confirmed cases of Lyme disease in Texas. Because of the potential for increased incidence and prevalence in Texas, it has become essential for research and clinical efforts to be diverted to the region. The Texas A&M College of Veterinary Medicine and Biomedical Sciences Lyme Lab has been investigating the ecology of Lyme disease in Texas and developing a pan-specific serological test for Lyme diagnosis. This report aimed to exposure materials and raise awareness of Lyme disease to healthcare providers.
Insights
Lyme disease, a tick-borne illness caused by Borrelia bacteria, is increasingly reported in Texas. Research efforts are focusing on understanding its ecology and developing diagnostic tools for this region.
Area of Science:
- Medical Entomology
- Infectious Diseases
- Neuroscience
Background:
- Lyme disease is a prevalent tick-borne illness in the US and Europe, caused by Borrelia bacteria.
- Neurological manifestations, including Lyme encephalopathy, are significant complications.
- Limited research exists on Lyme disease prevalence in Southern US states like Texas.
Purpose of the Study:
- To raise awareness among healthcare providers about Lyme disease in Texas.
- To highlight the need for increased research and clinical focus on Lyme disease in the region.
- To introduce ongoing research at Texas A&M's Lyme Lab.
Main Methods:
- Review of reported Lyme disease cases in Texas (2005-2014).
- Investigation into the ecology of Lyme disease in Texas.
- Development of a pan-specific serological diagnostic test.
Main Results:
- 582 confirmed Lyme disease cases reported in Texas between 2005 and 2014.
- Potential for increased incidence and prevalence in Texas necessitates further study.
- Texas A&M Lyme Lab is actively researching regional Lyme disease ecology and diagnostics.
Conclusions:
- There is a growing need to address Lyme disease in Texas due to reported cases.
- Enhanced research and clinical attention are crucial for understanding and managing Lyme disease in the Southern US.
- Development of improved diagnostic tools is essential for timely Lyme disease detection.
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