Related Experiment Video
Updated: Mar 16, 2026
07:49
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
20.1K
Suspected anaphylactic reaction associated with sugammadex: a case report
Jae Hwa Yoo1, Soon Im Kim1, Si Young Ok1
1Department of Anesthesiology and Pain Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Korean Journal of Anesthesiology
|August 3, 2016
Summary
A patient experienced a severe anaphylactic reaction to sugammadex, a drug used in anesthesia. Prompt treatment with epinephrine led to recovery, highlighting sugammadex
Area of Science:
- Anesthesiology
- Clinical Immunology
Background:
- Sugammadex is a reversal agent for neuromuscular blockade.
- Anaphylaxis is a rare but serious adverse reaction to medications.
Purpose of the Study:
- To report a case of suspected anaphylaxis to sugammadex.
- To raise awareness of the potential risks associated with sugammadex administration.
Main Methods:
- Case report of a 35-year-old male undergoing laparoscopic cholecystectomy.
- Observation of immediate post-administration symptoms and response to treatment.
- Skin prick testing performed 7 weeks post-event.
Main Results:
- The patient developed anaphylaxis symptoms (erythema, dyspnea, hypotension, tachycardia) within 2 minutes of sugammadex administration.
- Symptoms resolved rapidly following epinephrine administration.
- Skin prick test showed a weakly positive reaction to sugammadex.
Conclusions:
- Sugammadex administration can be associated with life-threatening anaphylaxis.
- Healthcare providers should be vigilant for anaphylactic reactions to sugammadex.
- Early recognition and management are crucial for patient outcomes.
Related Concept Videos
01:30Allergic Reactions: Anaphylaxis
116
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
116
01:30Drug Toxicity: Allergic Reactions
100
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
100
01:27Allergic Drug Reactions
1.6K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.6K
01:16Drug toxicity: Idiosyncratic Reactions
114
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
114
01:19Hypersensitivity Reactions: Immune-Complex Reactions
86
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
86
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
127
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
127