Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selected midline defect associations: a population study.

M J Khoury1, J F Cordero, J Mulinare

  • 1Birth Defects and Genetic Diseases Branch, Centers for Disease Control, US Department of Health and Human Services, Atlanta, Georgia 30333.

Pediatrics
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impacts of trace mineral source and ancillary drench on steer performance during a 60-day backgrounding phase.

Animal : an international journal of animal bioscience·2024
Same author

The role of epidemiology in informing United States childhood immunization policy and practice.

Annals of epidemiology·2020
Same author

A de novo splice site mutation in CASK causes FG syndrome-4 and congenital nystagmus.

American journal of medical genetics. Part A·2017
Same author

Simpson-Golabi-Behmel syndrome: an X-linked encephalo-tropho-schisis syndrome. 1988.

American journal of medical genetics. Part A·2013
Same author

The cardiofaciocutaneous syndrome.

Journal of medical genetics·2006
Same author

"Double-muscle" trait in cattle: a possible model for Wiedemann-Beckwith syndrome.

Fetal and pediatric pathology·2006
Same journal

Severe Postoperative Hypernatremia in an Adolescent Following Sleeve Gastrectomy.

Pediatrics·2026
Same journal

Barriers to Implementing SMART for Asthma in Pediatric Primary Care.

Pediatrics·2026
Same journal

Blood Lead Testing Among Children Enrolled in Medicaid.

Pediatrics·2026
Same journal

From Screening to Support: Crafting Social Needs Response Systems That Work for Families.

Pediatrics·2026
Same journal

A Social Care Intervention in Pediatric Practices: A Stepped Wedge Cluster Trial.

Pediatrics·2026
Same journal

Pediatric Cheerleading-Related Head Injuries and the "Double Down" Rule Change.

Pediatrics·2026
See all related articles

This study analyzed midline defects in infants, finding that while many occur alone, specific combinations are statistically associated. Understanding these patterns is crucial for exploring developmental causes of birth defects.

Area of Science:

  • Developmental Biology
  • Pediatric Genetics
  • Public Health

Background:

  • Midline defects are a group of congenital anomalies affecting various body structures.
  • Understanding the co-occurrence of these defects is vital for identifying underlying genetic and environmental factors.

Purpose of the Study:

  • To investigate the association between seven common midline defects using population-based data.
  • To identify specific patterns and combinations of co-occurring midline defects, excluding known syndromes.

Main Methods:

  • Utilized data from the Metropolitan Atlanta Congenital Defects Program.
  • Analyzed 1743 infants with at least one midline defect, focusing on neural tube defects, oral clefts, omphalocele, esophageal atresia/tracheoesophageal fistula, imperforate anus, conotruncal heart defects, and diaphragmatic hernia.

Related Experiment Videos

  • Performed pairwise analysis to determine statistical associations between defect types.

    • Main Results:

    • 4.9% of infants with one midline defect had at least a second, and 0.5% had two additional midline defects.
    • Specific combinations were observed, such as neural tube defects with cleft lip and imperforate anus with spina bifida.
    • Certain combinations were notably absent, including neural tube defects with conotruncal heart defects.

    Conclusions:

    • While most midline defects occur in isolation, specific associations exist, suggesting shared or related pathogenetic mechanisms.
    • Further research is needed to refine understanding of these associations in relation to embryology and pathogenesis.
    • Findings highlight the complexity of congenital anomalies and the importance of detailed pattern analysis.