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EXTRADIGESTIVE MANIFESTATIONS OF GASTROESOPHAGEAL REFLUX DISEASE: DEMOGRAPHIC, CLINICAL, BIOLOGICAL AND ENDOSCOPIC
Summary
Gastroesophageal reflux disease (GERD) with extradigestive symptoms is common and varied. This study found distinct demographic, clinical, and endoscopic differences among patients with GERD-related chronic laryngitis, asthma, or pseudoangina.
Area of Science:
- Gastroenterology and Hepatology
- Pulmonology
- Otolaryngology
- Cardiology
Background:
- Gastroesophageal reflux disease (GERD) is increasingly recognized for its extradigestive manifestations.
- These manifestations affect multiple medical specialties, including gastroenterology, pulmonology, otolaryngology, and cardiology.
- Understanding the diverse features of GERD with extradigestive symptoms is crucial for accurate diagnosis and management.
Purpose of the Study:
- To investigate the demographic, clinical, biological, and endoscopic characteristics of patients experiencing GERD with extradigestive manifestations.
- Specifically, the study focused on patients with chronic laryngitis, asthma, and pseudoangina as primary extradigestive symptoms.
- The aim was to identify differentiating factors among these patient subgroups.
Main Methods:
- A prospective case-control study was conducted with 137 patients referred to the Iasi Institute of Gastroenterology and Hepatology.
- Patients with typical GERD symptoms (heartburn or regurgitation) underwent upper digestive endoscopy.
- Impedance-pHmetry was performed for patients even in the absence of esophageal lesions to further assess GERD.
Main Results:
- Patients were categorized into three groups based on dominant extradigestive manifestation: chronic laryngitis (94), asthma (24), and pseudoangina (19).
- Pseudoangina patients showed higher prevalence of females (68.4%), obesity (52.6%), and dyslipidemia (57.9%) compared to other groups.
- While esophagitis was more frequent in the pseudoangina group (84.2%), no significant difference was found across the groups. Helicobacter pylori infection appeared potentially protective in pseudoangina patients.
Conclusions:
- GERD with extradigestive manifestations represents a prevalent yet heterogeneous condition.
- Significant demographic, clinical, biological, and endoscopic variations exist among patients presenting with different extradigestive symptoms of GERD.
- These findings underscore the need for tailored diagnostic and therapeutic approaches based on the specific extradigestive presentation.
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