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Boronic acid based imprinted electrochemical sensor for rutin recognition and detection
Chunlei Wang1, Qi Wang, Min Zhong
1College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing; The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, Anhui Normal University, Wuhu 241000, P.R. China. kanxw@mail.ahnu.edu.cn.
The Analyst
|August 4, 2016
Summary
A new electrochemical sensor using multi-walled carbon nanotubes and a molecular imprinting polymer detects rutin. This sensor offers high sensitivity and selectivity for rutin detection in tablets.
Area of Science:
- Electrochemistry
- Materials Science
- Analytical Chemistry
Background:
- Development of selective and sensitive electrochemical sensors is crucial for detecting bioactive compounds.
- Molecular imprinting polymers (MIPs) offer tailored recognition sites for specific analytes.
- Carbon nanomaterials enhance electrode performance due to their unique electrical properties.
Purpose of the Study:
- To fabricate a novel electrochemical sensor for the recognition and detection of rutin.
- To leverage the synergistic effects of multi-walled carbon nanotubes (MWNTs) and boronic acid-based MIPs for improved sensor performance.
Main Methods:
- Modification of a glassy carbon electrode with MWNTs and an APBA-based MIP.
- Electropolymerization of the MIP film in the presence of rutin as a template molecule.
- Optimization of sensor parameters including monomer ratios, electropolymerization conditions, and pH.
Main Results:
- The sensor exhibited high selectivity towards rutin due to imprinted cavities and the affinity between boronic acid and rutin's diols.
- The incorporation of MWNTs significantly enhanced the sensor's sensitivity for rutin detection.
- The optimized sensor demonstrated a linear detection range of 4.0 × 10⁻⁷ to 1.0 × 10⁻⁵ mol L⁻¹ with a detection limit of 1.1 × 10⁻⁷ mol L⁻¹.
Conclusions:
- The developed electrochemical sensor based on MWNTs and boronic acid MIP provides a sensitive and selective platform for rutin detection.
- The sensor shows practical applicability for the assay of rutin in pharmaceutical formulations like tablets.
