Laryngeal Verrucous Carcinoma.

Area of Science:

• Otolaryngology
• Oncology
• Pathology

Background:

• Laryngeal verrucous carcinoma (LVC) is a rare neoplasm, accounting for 1-3.4% of laryngeal cancers.
• Management strategies for LVC lack a definitive protocol based on T stage and presentation.

Purpose of the Study:

• To review the characteristics, treatment modalities, and patient outcomes of laryngeal verrucous carcinoma.
• To analyze demographic, tumor, and treatment variables from existing LVC case literature.

Main Methods:

• A comprehensive literature search was conducted across PubMed, MEDLINE, EMBASE, and Web of Science up to October 29, 2015.
• Individual patient cases of LVC were analyzed for demographics, tumor characteristics, treatment, and outcomes.

Main Results:

• 369 cases from 37 articles were reviewed; LVC predominantly affects males (13.8:1) at an average age of 58.7 years, often in the glottis (74.0%).
• Most patients presented with local disease (94.9%) and hoarseness (92.3%). Surgery alone was the primary treatment (72.3%), with local excision for T1 stage tumors (79.2%).
• Disease-free survival was high (86.8% overall, 88.6% for T1 stage), and overall survival was 80.3%.

Conclusions:

• Laryngeal verrucous carcinoma is typically managed surgically, with the extent of resection guided by T stage.
• Local excision is suitable for smaller tumors, while partial or total laryngectomy may be necessary for larger ones.
• LVC demonstrates a favorable posttreatment prognosis irrespective of T stage or specific therapy employed.