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Bupropion improved apathy in behavioral variant frontotemporal dementia: a case report
Chia-Pei Lin1, Chih-Pang Chu2, Hsing-Cheng Liu3,4
1a Department of Psychiatry , Taipei Medical University-Shuang Ho Hospital , New Taipei City , R.O.C.
Neurocase
|August 4, 2016
Summary
Bupropion may effectively treat apathy in behavioral variant frontotemporal dementia (bvFTD). This case study shows sustained improvement in apathy and imaging after 10 months of bupropion treatment for bvFTD.
Area of Science:
- Neuroscience
- Neurology
- Psychiatry
Background:
- Apathy is a prevalent neurobehavioral symptom in behavioral variant frontotemporal dementia (bvFTD).
- Currently, no consistently effective long-term treatments exist for apathy in bvFTD.
- This study explores a potential therapeutic avenue for managing apathy in bvFTD.
Observation:
- A 65-year-old male patient diagnosed with bvFTD presented with severe apathy.
- The patient underwent a 10-month treatment regimen with bupropion.
- Clinical and imaging assessments were conducted to monitor changes.
Findings:
- Bupropion treatment led to a significant improvement in the patient's apathy.
- Single-photon emission computed tomography (SPECT) scans indicated slight positive changes.
- This represents a novel case report of bupropion's efficacy in bvFTD-related apathy with imaging correlation.
Implications:
- Bupropion shows promise as a sustained treatment for apathy in bvFTD.
- Further research is warranted to validate these findings in larger cohorts.
- This case highlights the need for exploring pharmacological interventions for bvFTD symptoms.
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