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Updated: Mar 16, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
Therapeutic potential of coumarins as antiviral agents
Mohd Zaheen Hassan1, Hasnah Osman2, Mohamed Ashraf Ali3
1School of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800 Penang, Malaysia; Department of Pharmaceutical Chemistry, Alwar Pharmacy College, M.I.A., Alwar, Rajasthan 301030, India.
Abstract:
Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.
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