Related Experiment Video
Updated: Jul 31, 2026
Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging
Published on: January 5, 2015
Synthesis and characterization of a novel near-infrared fluorescent probe for applications in imaging A549 cells
Jing Xing1,2, Gaoxin Zhou1,2, Chunlong Sun3
1School of Biological Science & Medical Engineering, Southeast University, Nanjing, 210096, China.
Objective:
To design and synthesize a novel near-infrared (NIR) fluorescent probe based on indocyanine Green (ICG), that can be applied in imaging living cells.
Results:
A highly fluorescent novel NIR fluorescent probe (IR-793) was synthesized in two steps. IR-793 had better fluorescence and optical stability than ICG. In addition, no obvious cytotoxicity effect of IR-793 was observed and cell viability was above 75% at the maximum concentration (120 nM). IR-793 also exhibited good performance in imaging living A549 cells.
Conclusion:
IR-793, a novel NIR fluorescent probe that is stable, low-cost, highly fluorescent and low cytotoxicity, has been designed and synthesized for imaging living cells.
