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Developing a Behavioral Box for Assessing Prepulse Inhibition and Neural Activity in Psychiatric Animal Models
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Perimovement decrease of alpha/beta oscillations in the human nucleus accumbens.

Max-Philipp Stenner1, Stefan Dürschmid2, Robb B Rutledge3

  • 1Department of Neurology, Otto von Guericke University, Magdeburg, Germany; Department of Behavioral Neurology, Leibniz Institute for Neurobiology, Magdeburg, Germany; max-philipp.stenner@med.ovgu.de.

Journal of Neurophysiology
|August 4, 2016
PubMed
Summary
This summary is machine-generated.

The human nucleus accumbens directly aids action preparation and execution. Electrophysiological data show decreased alpha/beta oscillations in the nucleus accumbens during movement preparation.

Keywords:
action preparationbeta oscillationsdeep brain stimulationnucleus accumbens

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Electrophysiology

Background:

  • The nucleus accumbens is traditionally linked to reward and motivation.
  • Its role in real-time action selection and preparation is less understood.

Purpose of the Study:

  • To investigate the online role of the human nucleus accumbens during action preparation and execution.
  • To provide electrophysiological evidence for nucleus accumbens involvement in motor control.

Main Methods:

  • Local field potentials were recorded from the nucleus accumbens in epilepsy patients undergoing deep brain stimulation surgery.
  • Analysis focused on oscillatory power changes (alpha/beta frequencies) before and during movements in distinct tasks.

Main Results:

  • A significant decrease in alpha/beta oscillation power (10-30 Hz) was observed in the nucleus accumbens preceding and during movements.
  • This perimovement alpha/beta desynchronization occurred in 7/8 patients across instructed and self-paced tasks.
  • Similar beta decreases were noted in sensorimotor cortex and subthalamic nucleus, known areas for motor control.

Conclusions:

  • The human nucleus accumbens plays a direct, online role in action preparation and execution.
  • Electrophysiological findings support nucleus accumbens involvement in the motor preparation pathway.
  • This challenges previous notions and expands understanding of nucleus accumbens function.