Tableting Properties and Compression Models of Labisia pumila Tablets

Area of Science:

• Pharmaceutical Sciences
• Materials Science
• Pharmacognosy

Background:

• Labisia pumila is a medicinal herb with known therapeutic benefits.
• Understanding its tableting properties is crucial for developing effective herbal formulations.
• Traditional herbal preparations often lack standardized dosage forms.

Purpose of the Study:

• To investigate the tableting properties of Labisia pumila herbal powder.
• To determine the effect of compaction pressure and feed weight on tablet characteristics.
• To model the compressibility behavior of Labisia pumila tablets.

Main Methods:

• Compression of Labisia pumila herbal powder into tablets using a uniaxial die (13-mm diameter).
• Application of compaction pressures ranging from 7 to 25 MPa.
• Utilizing feed weights of 0.5 g and 1.0 g.
• Analysis of tablet strength, density, and porosity.
• Application of empirical models to describe compressibility.

Main Results:

• Tablet strength and density increased with increasing compaction pressure.
• Porosity of the tablets decreased as compaction pressure increased.
• Smaller feed weights and higher compaction forces resulted in more coherent tablets.
• Empirical models were applied to characterize compressibility behavior.

Conclusions:

• Compaction pressure and feed weight significantly influence the tableting properties of Labisia pumila.
• Optimized compression parameters can yield tablets with improved strength, density, and coherence.
• Findings enhance the understanding and approach to formulating Labisia pumila herbal tablets.