Correlation between visit-to-visit and short-term blood pressure variability calculated using different methods and...

Area of Science:

• Nephrology
• Cardiology
• Geriatrics

Background:

• Blood pressure variability (BPV) is an independent risk factor for cardiovascular and renal diseases.
• Understanding the relationship between different BPV metrics and kidney function is crucial for risk stratification in aging populations.
• Previous studies have shown associations between BPV and chronic kidney disease, but specific metrics and their correlation with estimated glomerular filtration rate (eGFR) require further investigation.

Purpose of the Study:

• To investigate the correlation between visit-to-visit and short-term blood pressure variability (BPV), including systolic (SBPV) and diastolic (DBPV), calculated using various methods.
• To assess the relationship between these BPV metrics and estimated glomerular filtration rate (eGFR) in a population of late middle-aged and older adults.

Main Methods:

• Cluster sampling was used to select 2464 retired employees aged 60 years or older for 24-hour ambulatory blood pressure monitoring.
• BPV was calculated using standard deviation (s.d.), coefficient of variation (CV), variability independent of mean (VIM), and blood pressure variability ratio (BPVR).
• Multivariate linear regression analysis was employed to examine the association between eGFR and BPV metrics, controlling for confounding factors.

Main Results:

• Systolic BPV (SBPV) calculated using different methods showed statistically significant increasing trends.
• Both visit-to-visit and short-term BPV metrics demonstrated a significant positive correlation with each other.
• All calculated BPV metrics, including SBPV and diastolic BPV (DBPV), were negatively correlated with eGFR (P<0.05).
• Multivariate analysis confirmed negative linear relationships between SBPV (using 24-h s.d., CV, VIM, daytime CV, and nighttime CV) and DBPV with eGFR.

Conclusions:

• Increased blood pressure variability, encompassing both systolic and diastolic measures, is significantly associated with reduced kidney function (lower eGFR) in older adults.
• The findings highlight the importance of considering BPV as a potential indicator of renal health decline in this demographic.
• Different methods of calculating BPV consistently showed a negative impact on eGFR, suggesting robustness of the observed relationship.