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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Mar 16, 2026

Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia
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Intra-Arterial Delivery of Neural Stem Cells to the Rat and Mouse Brain: Application to Cerebral Ischemia

Published on: June 26, 2020

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Neural Stem Cells and Ischemic Brain.

Zhenggang Zhang1, Michael Chopp1,2

  • 1Henry Ford Hospital, Michigan, United States.

Journal of Stroke
|August 5, 2016
PubMed
Summary
This summary is machine-generated.

Stroke activates neural stem cells, increasing neuroblasts and oligodendrocyte progenitor cells (OPCs). Intercellular communication aids ischemic brain repair, though neuronal replacement is unlikely. This review explores these repair mechanisms.

Keywords:
Adult neurogenesisBrain repairStem cellsStroke

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Area of Science:

  • Neuroscience
  • Stem Cell Biology
  • Cerebrovascular Research

Background:

  • Stroke triggers neural stem cell activation in the ventricular-subventricular zone (V/SVZ).
  • This activation leads to increased neuroblasts and oligodendrocyte progenitor cells (OPCs).
  • These cells interact with brain parenchymal and endothelial cells post-stroke.

Approach:

  • This mini-review synthesizes recent findings on intercellular communication.
  • Focuses on the roles of neurogenesis and oligodendrogenesis in stroke repair.
  • Examines the communication between neural progenitor cells and brain cells.

Key Points:

  • Stroke-induced neural stem cells, neuroblasts, and OPCs actively communicate within the ischemic brain.
  • This communication appears crucial for mediating ischemic brain repair processes.
  • Neuronal replacement via stroke-induced neurogenesis is considered unlikely.

Conclusions:

  • Intercellular communication involving neurogenesis and oligodendrogenesis is a key mechanism in stroke brain repair.
  • Understanding these interactions may reveal therapeutic targets for stroke recovery.
  • Further research into these communication pathways is warranted for effective stroke treatment strategies.