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Updated: Mar 16, 2026

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Diffusivity in multiple sclerosis lesions: At the cutting edge?

Alexander Klistorner¹, Chenyu Wang², Vera Fofanova³

¹Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, Australia; Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

Neuroimage. Clinical

|August 5, 2016

Summary

This summary is machine-generated.

Radial diffusivity (RD) in MS lesions is affected by tissue destruction, masking remyelination. The T2 lesion edge, less affected by tissue loss, is a better target for imaging biomarkers of de- and remyelination.

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Last Updated: Mar 16, 2026

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Area of Science:

Neuroimaging
Biomarker Development
Multiple Sclerosis Research

Background:

Radial diffusivity (RD) is a potential biomarker for myelination in MS lesions.
However, RD is influenced by both myelin loss and tissue destruction, potentially obscuring remyelination effects.

Purpose of the Study:

To investigate if the T2 lesion edge (T1-isointense rim) is a more suitable region than the T1-hypointense core for imaging biomarkers of de- and remyelination.
Hypothesizing that the T2 lesion edge is less affected by tissue loss.

Main Methods:

Diffusion tensor imaging (DTI) and contrast-enhanced T1/T2 MRI were acquired from 75 RRMS patients.
T2 lesions were segmented into T1-hypointense (core) and T1-isointense (rim) areas.
Diffusivity metrics (RD, AD, MD) and FA were calculated for lesion components, excluding enhancing lesions.

Main Results:

Chronic T2 lesions predominantly featured a T1-hypointense core (approx. 40% volume) and a peripheral T1-isointense "T2-rim".
The "T2-rim" showed a disproportionately higher increase in RD compared to AD relative to normal white matter.
Diffusivity increases were similar between the "T2-rim" and the T1-hypointense core.

Conclusions:

Distinct diffusivity patterns suggest axonal loss dominates the T1-hypointense lesion core.
The "T2-rim" may better reflect de/remyelination due to preserved structural integrity.
Separating these lesion components is crucial for evaluating neuroprotective and remyelinating therapies in MS clinical trials.