Related Experiment Video
Updated: Mar 16, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
Published on: August 16, 2021
Critical Heart Failure and Shock
Ronald A Bronicki1, Mary Taylor, Harris Baden
11Department of Pediatrics, Critical Care Medicine and Cardiology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX. 2Department of Pediatrics, Critical Care Medicine and Cardiology, University of Mississippi Medical Center, Batson Children's Hospital, Jackson, MS. 3Department of Pediatrics, Critical Care Medicine, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, WA.
Insights
This review covers shock management in children, focusing on circulatory physiology and pharmacologic strategies to optimize oxygen delivery. Understanding shock pathophysiology is crucial for effective assessment and improved patient outcomes.
Area of Science:
- Pediatric critical care medicine
- Cardiovascular physiology
- Pharmacology
Background:
- Shock is a critical condition requiring understanding of circulatory physiology.
- Effective management hinges on assessing cardiac function and tissue oxygenation.
- Optimizing oxygen delivery and consumption is key to improving outcomes.
Purpose of the Study:
- To review the clinical assessment, pathophysiology, and management of shock in children.
- To emphasize circulatory physiology, cardiopulmonary interactions, and pharmacologic strategies.
- To apply these principles to pediatric heart failure and cardiogenic shock.
Main Methods:
- Literature review of MEDLINE and PubMed databases.
- Synthesis of information on shock pathophysiology and management.
- Application of physiological principles to pediatric clinical syndromes.
Main Results:
- Detailed discussion of shock assessment and underlying pathophysiology.
- Exploration of pharmacologic interventions to enhance systemic oxygen delivery.
- Emphasis on the interplay between circulatory and cardiopulmonary systems.
Conclusions:
- Understanding circulatory physiology and shock pathophysiology is essential for managing at-risk children.
- Accurate assessment of cardiac output and tissue oxygenation is critical.
- Optimizing the balance between oxygen delivery and consumption improves patient outcomes.
Objectives:
The objectives of this review are to discuss the clinical assessment, pathophysiology, and management of shock, with an emphasis on circulatory physiology, cardiopulmonary interactions, and pharmacologic strategies to optimize systemic oxygen delivery. These principles will then be applied to the clinical syndromes of heart failure and cardiogenic shock that are seen in children.
Data Source:
MEDLINE, PubMed.
Conclusion:
An understanding of essential circulatory physiology and the pathophysiology of shock are necessary for managing patients at risk for or in a state of shock. A timely and accurate assessment of cardiac function, cardiac output, and tissue oxygenation and the means by which to enhance the relationship between oxygen delivery and consumption are essential in order to optimize outcomes.
Related Concept Videos
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Heart Failure I: Introduction
Heart Failure III: Clinical Manifestations
Pathophysiology of Heart Failure
Heart Failure V: Medical Management
Heart Failure IV: Classification and Diagnostic Evaluation

