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In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
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Astigmatism corrected common path probe for optical coherence tomography.

Kanwarpal Singh1,2, Daisuke Yamada1,3, Guillermo Tearney1,2

  • 1Wellman Center for Photomedicine, Massachusetts General Hospital, 55 Fruit Street, Boston, 02114, Massachusetts.

Lasers in Surgery and Medicine
|August 5, 2016
PubMed
Summary
This summary is machine-generated.

This study developed a new optical coherence tomography (OCT) probe to minimize imaging artifacts. The novel common-path, astigmatism-corrected probe enhances image quality for intraluminal imaging applications.

Keywords:
aberration compensationimaging systems

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Area of Science:

  • Biomedical Optics
  • Medical Imaging Technology

Background:

  • Intraluminal imaging using optical coherence tomography (OCT) catheters faces artifacts from dispersion imbalances and beam astigmatism.
  • These artifacts degrade image quality and limit diagnostic accuracy in OCT applications.

Purpose of the Study:

  • To develop an OCT probe designed to minimize artifacts common in intraluminal imaging.
  • To create a probe that corrects for astigmatism and reduces dispersion imbalances.

Main Methods:

  • Fabrication of a common-path probe using single-mode fiber, a graded index lens, and a curved reflector.
  • Optimization of the probe design using Zemax optical software.
  • Testing the probe's performance with a custom spectrometer-based OCT system.

Main Results:

  • The developed OCT probe achieved high axial resolution (15.6 μm) and lateral resolution (33 μm) with 103 dB sensitivity.
  • Imaging of a tissue phantom demonstrated effective astigmatism correction and minimal artifacts.
  • The common-path design successfully reduced artifacts in both axial and lateral dimensions.

Conclusions:

  • A novel astigmatism-corrected, common-path OCT probe was successfully developed.
  • This probe design effectively minimizes artifacts, improving image quality for intraluminal OCT.
  • The probe is suitable for OCT applications demanding high axial and lateral resolution.