Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conservation of Mass in Fixed, Nondeforming Control Volume01:07

Conservation of Mass in Fixed, Nondeforming Control Volume

1.7K
The principle of conservation of mass is fundamental in fluid dynamics and is crucial for analyzing flow within fixed control volumes, such as pipes or ducts. This principle states that the total mass within a control volume remains constant unless altered by the inflow or outflow of mass through the control surfaces. This results in a vital relationship for steady, incompressible flow where the mass entering a system equals the mass leaving it.
In the case of a sewer pipe, which can be modeled...
1.7K
Isotonic and Isometric Muscle Contractions01:22

Isotonic and Isometric Muscle Contractions

8.6K
Two primary types of muscle contractions are isotonic and isometric, each serving unique functions and involving distinct mechanisms. Both isotonic and isometric contractions are integral to the body's complex system of movement and stability. Isotonic exercises contribute significantly to functional strength and movement, while isometric contractions are crucial for maintaining posture and joint stability.
Isotonic contractions
Isotonic contractions occur when a muscle changes length while...
8.6K
Conservation of Mass in Moving, Nondeforming Control Volume01:14

Conservation of Mass in Moving, Nondeforming Control Volume

1.4K
Stormwater detention basins are essential in managing runoff during heavy rainfall, particularly in urban areas where impervious surfaces increase the risk of flooding. Understanding the conservation of mass in these systems allows engineers to optimize basin performance, balancing inflow, outflow, and water storage.
In the context of a detention basin, the conservation of mass states that the total mass of water entering the basin must equal the mass leaving the basin plus any accumulation of...
1.4K
Cross-bridge Cycle01:26

Cross-bridge Cycle

124.3K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
124.3K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.2K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.2K
Skeletal Muscle Anatomy00:55

Skeletal Muscle Anatomy

94.4K
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
94.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of ErbB2 mitigates secondary denervation after traumatic muscle injury.

The Journal of physiology·2025
Same author

Differential evaluation of neuromuscular injuries to understand re-innervation at the neuromuscular junction.

Experimental neurology·2024
Same author

Response of terminal Schwann cells following volumetric muscle loss injury.

Experimental neurology·2023
Same author

Minced muscle autografting improves bone healing but not muscle function in a porcine composite injury model.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2023
Same author

Retrospective characterization of a rat model of volumetric muscle loss.

BMC musculoskeletal disorders·2022
Same author

In Vivo Measurement of Hindlimb Dorsiflexor Isometric Torque from Pig.

Journal of visualized experiments : JoVE·2021
Same journal

Mapping the 3D Chromosome Organization of a Biosynthetic Gene Cluster by Capture Hi-C (CHi-C).

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Mapping the 3D Chromosome Organization of Streptomyces by Hi-C.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

CUT&Tag Epigenomic Profiling of Biosynthetic Gene Clusters in Arabidopsis thaliana.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Rhizobium rhizogenes-Mediated Hairy Root Transformation Protocol for Lotus japonicus and Other Legumes.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Characterization of Bioactive Saponins from Sea Cucumbers.

Methods in molecular biology (Clifton, N.J.)·2026
Same journal

Methods for Functional Validation of Terpenoid Metabolic Clusters in Nicotiana benthamiana and Aspergillus oryzae.

Methods in molecular biology (Clifton, N.J.)·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury
06:46

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

Published on: November 15, 2024

1.1K

Volumetric Muscle Loss.

Beth E Pollot1, Benjamin T Corona2

  • 1Extremity Trauma and Regenerative Medicine, United States Army Institute of Surgical Research, 3698 Chambers Pass, Bldg 3611, Fort Sam Houston, TX, 78234-6315, USA.

Methods in Molecular Biology (Clifton, N.J.)
|August 6, 2016
PubMed
Summary
This summary is machine-generated.

This study introduces a novel volumetric muscle loss (VML) model for studying muscle regeneration. This validated model allows for repeated strength assessments in mice, rats, and pigs.

Keywords:
ForceMouseMusculoskeletal traumaOrthopedicPigRatRegenerative medicineSkeletal muscle injuryTorque

More Related Videos

Rodent Model of Masseter Volumetric Muscle Loss for Studying Bioengineering Materials
03:46

Rodent Model of Masseter Volumetric Muscle Loss for Studying Bioengineering Materials

Published on: May 31, 2024

924
3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue
08:52

3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue

Published on: November 27, 2017

24.4K

Related Experiment Videos

Last Updated: Mar 16, 2026

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury
06:46

In Vivo Functional Assessment of Rat Masseter Muscle Following Surgical Creation of a Volumetric Muscle Loss (VML) Injury

Published on: November 15, 2024

1.1K
Rodent Model of Masseter Volumetric Muscle Loss for Studying Bioengineering Materials
03:46

Rodent Model of Masseter Volumetric Muscle Loss for Studying Bioengineering Materials

Published on: May 31, 2024

924
3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue
08:52

3D Ultrasound Imaging: Fast and Cost-effective Morphometry of Musculoskeletal Tissue

Published on: November 27, 2017

24.4K

Area of Science:

  • Orthopedics
  • Regenerative Medicine
  • Muscle Physiology

Background:

  • Volumetric muscle loss (VML) is a severe injury resulting from abrupt tissue loss, distinct from other rodent injury models.
  • VML is prevalent in extremity trauma, necessitating research into muscle regeneration and strength restoration.
  • Current research aims to regenerate lost muscle tissue to improve functional outcomes.

Purpose of the Study:

  • To describe a novel volumetric muscle loss (VML) model in the anterior hindlimb compartment.
  • To validate this VML model for its suitability for repeated neuromuscular strength assessments.
  • To confirm the model's applicability across different species, including mouse, rat, and pig.

Main Methods:

  • Development of a VML model in the anterior compartment of the hindlimb.
  • Implementation of protocols for repeated neuromuscular strength assessments.
  • Validation of the model in mouse, rat, and pig models.

Main Results:

  • A functional VML model was successfully established in the anterior hindlimb compartment.
  • The model demonstrated suitability for serial neuromuscular strength evaluations.
  • The VML model was validated across mouse, rat, and pig species.

Conclusions:

  • The described VML model provides a robust platform for studying muscle regeneration and strength recovery.
  • This validated, multi-species model facilitates translational research in VML injury.
  • The model's capacity for repeated strength testing is crucial for evaluating therapeutic interventions.