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Treatment of hyperuricemia in gout: current therapeutic options, latest developments and clinical implications

Sebastian E Sattui1, Angelo L Gaffo2

  • 1Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Therapeutic Advances in Musculoskeletal Disease
|August 6, 2016
PubMed

Insights

Gout management is improving with new therapies targeting hyperuricemia. Emerging drugs show promise for better control of high uric acid levels and reducing gout complications.

Area of Science:

  • Rheumatology
  • Pharmacology

Background:

  • Gout, the most common inflammatory arthritis, is frequently poorly managed.
  • Hyperuricemia is linked to cardiometabolic issues and poor patient outcomes like disability.

Purpose of the Study:

  • To review current gout therapeutic strategies and their limitations.
  • To discuss emerging agents for chronic hyperuricemia management in gout.

Main Methods:

  • Review of current literature on gout management.
  • Analysis of drugs in development (Phases I and II).

Main Results:

  • Limited therapeutic options for hyperuricemia have existed for decades.
  • New uricosurics (e.g., lesinurad, arhalofenate) are developed based on renal urate transporter knowledge.

Conclusions:

  • Emerging agents, including purine nucleoside phosphorylase inhibitors and dual-action drugs, offer hope.
  • New developments may lead to more adequate hyperuricemia management in gout patients.

Keywords:
URAT1arhalofenategouthyperuricemialesinuradulodesineurate-lowering therapy

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