Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.7K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

248
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
248
Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

114
Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
114
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

313
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
313
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

716
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
716

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Consensus expert recommendations for management of dysphagia during hospital admission in Parkinson's disease.

Journal of Parkinson's disease·2026
Same author

Thermoregulatory Dysfunction in Parkinson's Disease: Mechanisms, Implications, and Therapeutic Perspectives.

Cells·2025
Same author

Consensus practice recommendations for management of gastrointestinal dysfunction in Parkinson disease.

Parkinsonism & related disorders·2024
Same author

Neurogastroenterology.

Seminars in neurology·2023
Same author

Movement Disorders and the Gut: A Review.

Movement disorders clinical practice·2022
Same author

Gastrointestinal Dysfunction in Parkinson's Disease.

Drugs·2022
Same journal

Key Considerations in Telestroke Program Management.

Continuum (Minneapolis, Minn.)·2026
Same journal

Neurology's Action Potential: Delivering on the Promise of Brain Health.

Continuum (Minneapolis, Minn.)·2026
Same journal

Erratum.

Continuum (Minneapolis, Minn.)·2026
Same journal

Management of Large Artery Atherosclerosis.

Continuum (Minneapolis, Minn.)·2026
Same journal

Thrombolysis, Thrombectomy, and Antithrombotic Therapy for Acute Ischemic Stroke.

Continuum (Minneapolis, Minn.)·2026
Same journal

Stroke in Children and Younger Adults.

Continuum (Minneapolis, Minn.)·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
06:52

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

2.1K

Wilson Disease.

Ronald F Pfeiffer

    Continuum (Minneapolis, Minn.)
    |August 7, 2016
    PubMed
    Summary
    This summary is machine-generated.

    Wilson disease is a rare genetic disorder with varied symptoms affecting the brain and liver. Early diagnosis and treatment are crucial to prevent irreversible damage.

    More Related Videos

    Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
    11:04

    Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

    Published on: September 7, 2019

    10.0K
    Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
    09:21

    Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

    Published on: February 23, 2024

    1.6K

    Related Experiment Videos

    Last Updated: Mar 16, 2026

    Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
    06:52

    Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

    Published on: April 28, 2023

    2.1K
    Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
    11:04

    Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

    Published on: September 7, 2019

    10.0K
    Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
    09:21

    Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

    Published on: February 23, 2024

    1.6K

    Area of Science:

    • Genetics
    • Neurology
    • Hepatology

    Background:

    • Wilson disease is a rare, inherited disorder of copper metabolism.
    • It leads to copper accumulation in organs, primarily the liver and brain.
    • Clinical manifestations are diverse, often presenting with neurologic and psychiatric symptoms.

    Purpose of the Study:

    • To review the clinical features of Wilson disease.
    • To focus on neurologic and psychiatric abnormalities.
    • To outline diagnostic workup and treatment strategies.

    Main Methods:

    • Literature review of clinical features, diagnostics, and therapeutics for Wilson disease.
    • Analysis of current understanding of genetic mutations.
    • Evaluation of diagnostic testing and treatment protocols.

    Main Results:

    • The spectrum of Wilson disease mutations is expanding.
    • Genetic testing is becoming more accessible for suspected cases.
    • Timely diagnosis and treatment are essential for patient outcomes.

    Conclusions:

    • Wilson disease should be considered in unexplained neurologic, psychiatric, or hepatic dysfunction.
    • Prompt diagnostic evaluation and initiation of treatment are critical.
    • Delayed diagnosis and treatment lead to progressive, irreversible organ damage.