RIFM fragrance ingredient safety assessment, Isopulegol, CAS Registry Number 89-79-2

Area of Science:

• Toxicology and Environmental Safety

Background:

• Comprehensive safety assessments are crucial for new materials.
• Evaluating multiple toxicity endpoints ensures a thorough understanding of potential risks.

Purpose of the Study:

• To evaluate the genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety of a specific material.

Main Methods:

• Genotoxicity and skin sensitization were directly assessed.
• Repeated dose, developmental and reproductive, and local respiratory toxicity were evaluated using the Threshold of Toxicological Concern (TTC) for Cramer Class I materials.
• Phototoxicity/photoallergenicity was determined using UV spectra.
• Environmental safety was assessed following the RIFM Framework.

Main Results:

• The material was found to be not genotoxic.
• The material does not possess skin sensitization potential.
• Toxicity endpoints were evaluated based on established safety thresholds and spectral data.

Conclusions:

• The material demonstrates a favorable safety profile regarding genotoxicity and skin sensitization.
• The use of TTC and UV spectra provided a scientifically sound basis for evaluating other toxicity endpoints.
• The comprehensive safety evaluation supports the safe use of this material.