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O-GlcNAcylation and neurodegeneration

Willayat Y Wani1, John C Chatham1, Victor Darley-Usmar1

  • 1Center for Free Radical Biology, Developmental and Integrative Biology, University of Alabama at Birmingham, United States; Department of Pathology, Developmental and Integrative Biology, University of Alabama at Birmingham, United States.

Brain Research Bulletin
|August 8, 2016
PubMed
Summary

O-GlcNAcylation, a protein modification, plays a role in neurodegenerative diseases like Alzheimer's. Enhancing O-GlcNAc levels may offer neuroprotection by reducing Tau phosphorylation and toxicity.

Keywords:
AgingAmyloidAutophagyHuntingtinOGAOGTSynucleinTau

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