An annulative transfer hydrogenation strategy enables straightforward access to tetrahydro fused-pyrazine derivatives
Biao Xiong1, Shu-Di Zhang1, Lu Chen2
1Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering and State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Wushan Rd-381, Guangzhou 510641, People's Republic of China.
Abstract:
A ruthenium-catalysed annulative transfer hydrogenation strategy, enabling straightforward access to tetrahydro fused-pyrazine derivatives from N-heteroaryl diamines and vicinal diols, has been demonstrated for the first time. Such a synthesis proceeds with unprecedented synthetic effectiveness including high step- and atom efficiency, generation of water as the sole by-product, short reaction time and no need for external high pressure H2 gas, offering an important basis for the transformation of vicinal diols, a class of bio-mass derived resources, into functionalized products.
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