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Updated: Mar 16, 2026
Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
New inflammatory parameters in laryngopharyngeal reflux
H Arslan1, T Çandar2, S Kuran3
1Department of Otorhinolaryngology,Ufuk University Medical School,Ankara,Turkey.
New inflammatory markers, platelet-to-lymphocyte ratio and mean platelet volume, show promise for diagnosing and monitoring laryngopharyngeal reflux (LPR). Higher platelet-to-lymphocyte ratios and lower mean platelet volumes were observed in LPR patients, with improvements correlating to treatment.
Area of Science:
- Otolaryngology
- Inflammation Research
- Hematology
Background:
- Laryngopharyngeal reflux (LPR) is a condition characterized by the reflux of stomach contents into the larynx and pharynx.
- Identifying reliable inflammatory markers for LPR diagnosis and treatment monitoring is crucial.
Purpose of the Study:
- To investigate platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) as novel inflammatory markers in LPR patients.
- To determine if these markers change in response to LPR treatment.
Main Methods:
- Complete blood count parameters, including platelet count, MPV, neutrophil-to-lymphocyte ratio (NLR), and PLR, were analyzed.
- LPR patients received a three-month course of lansoprazole treatment.
Main Results:
- LPR patients exhibited significantly higher PLR and lower MPV compared to healthy controls.
- PLR correlated significantly with initial inflammatory symptoms (Reflux Symptom Index and Reflux Finding Score).
- Increased MPV correlated with symptom improvement during lansoprazole treatment.
Conclusions:
- Platelet-to-lymphocyte ratio serves as a valuable indicator of chronic inflammation in LPR.
- Mean platelet volume is a potential biomarker for treatment response in LPR patients.
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