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[Wernicke-Korsakoff syndrome].

S V Kotov¹, A I Lobakov¹, E V Isakova¹

¹M.F. Vladimirski Moscow Regional Research Institute, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova

|August 9, 2016

Summary

Non-alcoholic Wernicke-Korsakoff syndrome (WKS) in gastrointestinal disease patients requires prompt thiamine treatment. Early diagnosis and vitamin B therapy can prevent severe cognitive deficits.

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Area of Science:

Neurology
Gastroenterology
Nutritional Science

Background:

Non-alcoholic Wernicke-Korsakoff syndrome (WKS) is a serious neurological complication.
Gastrointestinal tract (GIT) diseases, malabsorption, and upper GIT surgery increase WKS risk.

Purpose of the Study:

To investigate the diagnosis and treatment of non-alcoholic Wernicke-Korsakoff syndrome (WKS).

Main Methods:

Study included eight patients with WKS linked to GIT disease, malabsorption, or post-surgery.
Clinical manifestations, MRI findings, and treatment responses were analyzed.

Main Results:

Patients presented with consciousness disturbance, ataxia, eye movement disorders, and bulbar syndrome within 24-48 hours.
MRI showed characteristic brain lesions in the hypothalamus, mamillary bodies, brain stem, and hippocampus.
Treatment with vitamin B complex and thiamine demonstrated a positive therapeutic effect.

Conclusions:

Patients with GIT disease and malabsorption are identified as a high-risk group for WKS.
Prompt recognition of neurological symptoms and initiation of thiamine treatment are crucial.
Timely thiamine administration can prevent the development of irreversible cognitive deficits.