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Polyomavirus Persistence.

Michael J Imperiale1, Mengxi Jiang2

  • 1Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan 48109;

Annual Review of Virology
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PubMed
Summary

Mammalian polyomaviruses cause persistent infections, but their reactivation mechanisms remain unclear. This review summarizes current knowledge on these viruses, highlighting gaps in understanding human polyomavirus persistence.

Keywords:
persistencepolyomavirusreactivation

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Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Mammalian polyomaviruses establish persistent infections in healthy individuals.
  • Disease manifestation typically occurs in immunocompromised hosts.
  • Decades after discovery, mechanisms of viral persistence and reactivation are poorly understood.

Purpose of the Study:

  • To review the current state of knowledge on mammalian polyomaviruses.
  • To identify gaps in understanding viral persistence and reactivation.
  • To suggest future research directions for human polyomaviruses.

Main Methods:

  • Literature review of existing studies on mammalian polyomaviruses.
  • Analysis of data from mouse polyomavirus research.
  • Inference of human polyomavirus behavior from related studies.

Main Results:

  • Limited understanding of the specific mechanisms governing polyomavirus persistence and reactivation.
  • Mouse polyomavirus is relatively well-studied compared to human counterparts.
  • Knowledge on human polyomaviruses is largely extrapolated.

Conclusions:

  • Significant knowledge gaps exist regarding mammalian polyomavirus persistence and reactivation.
  • Further targeted research is needed, particularly for human polyomaviruses.
  • Understanding these viruses is crucial for managing opportunistic infections.