Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Condensins02:15

Condensins

4.8K
Condensins are large protein complexes that use ATP to fuel the assembly of chromosomes during mitosis. They transform the tangled, shapeless mass of post-interphase DNA into individualized chromosomes by compacting, organizing, and segregating chromosomal DNA.
The plant and animal cells contain two types of condensin complexes—condensin I and condensin II. Both complexes have five subunits: two SMC (Structural Maintenance of Chromosomes) subunits, a kleisin subunit, and two HEAT-repeat...
4.8K
Condensins02:15

Condensins

2.2K
2.2K
DNA Packaging00:58

DNA Packaging

114.5K
Overview
114.5K
Chromatin Packaging01:32

Chromatin Packaging

20.1K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
20.1K
Chromatin Packaging02:21

Chromatin Packaging

22.9K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.9K
Newman Projections02:06

Newman Projections

23.4K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
23.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A high-endurance DNA origami snap-through switch for functional nanoscale control.

Science robotics·2026
Same author

A nanoscale Jitterbug transformer from DNA.

Nature communications·2026
Same author

Vesicle-Templated Self-Assembly of Programmable Freestanding Multi-μm DNA Shells.

Nano letters·2026
Same author

Operating CRISPR/Cas12a in a complex nucleic acid sequence background.

Nucleic acids research·2026
Same author

Quantifying phage-host dynamics using droplet microfluidics.

Nature communications·2026
Same author

Autonomous biogenesis of all thirty proteins of the Escherichia coli translation machinery.

Nature communications·2025

Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.5K

DNA condensation in one dimension.

Günther Pardatscher1, Dan Bracha2, Shirley S Daube2

  • 1Systems Biophysics and Bionanotechnology - E14, Physics-Department and ZNN, Technische Universität München, 85748 Garching, Germany.

Nature Nanotechnology
|November 8, 2016
PubMed
Summary
This summary is machine-generated.

Researchers created long, 1D DNA fibers on a biochip, overcoming previous size limitations for DNA nanostructures. This breakthrough enables new applications in nanoscale templating and problem-solving circuits.

More Related Videos

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K
Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

2.8K

Related Experiment Videos

Last Updated: Mar 16, 2026

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

1.5K
Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules
09:32

Stable DNA Motifs, 1D and 2D Nanostructures Constructed from Small Circular DNA Molecules

Published on: April 12, 2019

7.2K
Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA
07:05

Single-Molecule Imaging of EWS-FLI1 Condensates Assembling on DNA

Published on: September 8, 2021

2.8K

Area of Science:

  • Nanotechnology
  • Molecular Biology
  • Materials Science

Background:

  • DNA nanostructures offer nanoscale templating for devices like wires and transistors.
  • Current DNA nanostructures are limited to sub-micrometer sizes due to strand length and sequence constraints.

Purpose of the Study:

  • To develop a method for creating significantly longer DNA nanostructures.
  • To explore the properties and potential applications of these extended DNA structures.

Main Methods:

  • DNA chains were patterned on a biochip using electron beam writing on a photocleavable monolayer.
  • DNA molecules were induced to condense into one-dimensional (1D) fibers using spermidine.

Main Results:

  • Achieved formation of 1D DNA fibers, 20 nm wide and up to 70 µm long, composed of approximately 35 co-aligned DNA chains.
  • Observed DNA condensation propagation, splitting at junctions, gap crossing, and domain wall formation.
  • Demonstrated the system's ability to solve probabilistic problems, including maze navigation and stochastic switching circuit evaluation.

Conclusions:

  • This technique overcomes previous length limitations for DNA nanostructures, enabling the creation of large-scale, ordered DNA assemblies.
  • The programmable 1D DNA fibers show potential for signal propagation and gene expression in cell-free systems.
  • The developed system offers a novel platform for nanoscale engineering and computation.