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Decrease of pulmonary blood flow detected by phase contrast MRI is correlated with a decrease in lung volume and

Nanae Tsuchiya1, Tsuneo Yamashiro1, Sadayuki Murayama1

  • 1Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, 207 Uehara, Nishihara-Cho, Nakagami-Gun, Okinawa 903-0215, Japan.

European Journal of Radiology
|August 10, 2016
PubMed
Abstract

Insights

Pulmonary blood flow and lung volume decrease in interstitial lung disease (ILD). This study found reduced pulmonary blood flow is linked to smaller lung volumes and more severe lung damage in ILD patients.

Area of Science:

  • Cardiovascular Imaging
  • Pulmonary Medicine
  • Radiology

Background:

  • Interstitial lung disease (ILD) is characterized by decreased lung volume and pulmonary blood flow.
  • Understanding the relationship between these factors is crucial for ILD management.

Purpose of the Study:

  • To assess the relationship between pulmonary blood flow and lung volume in patients with ILD.
  • To investigate the correlation between pulmonary blood flow, lung volume, and ILD severity.

Main Methods:

  • Phase contrast magnetic resonance imaging (MRI) was used to measure pulmonary blood flow in the pulmonary trunk and arteries.
  • Thin-section computed tomography (CT) scanning assessed lung volume and ILD severity (CT visual score).
  • Pearson's correlation coefficient and partial correlation analysis were employed to determine relationships.

Main Results:

  • Significant positive correlations were found between pulmonary blood flow and lung volume (r=0.52, p=0.006).
  • Significant negative correlations were observed between pulmonary blood flow and CT visual score (r=-0.39, p=0.04).
  • These correlations remained significant after controlling for age, height, and weight.

Conclusions:

  • Reduced pulmonary blood flow is associated with reduced lung volume in ILD patients.
  • Increased abnormal lung area (higher CT visual score) correlates with decreased pulmonary blood flow.
  • These findings highlight the interconnectedness of vascular and volumetric changes in ILD.
Keywords:
Interstitial lung diseaseLung fibrosisLung volumePhase contrast MRIPulmonary blood flow

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