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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Mar 16, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis

Published on: March 31, 2015

Genomic and Transcriptomic Approaches to Study Cancer in Small Aquarium Fish Models.

J Regneri¹, B Klotz¹, M Schartl²

¹University of Würzburg, Würzburg, Germany.

Advances in Genetics

|August 10, 2016

Summary

This summary is machine-generated.

Zebrafish and medaka tumor models offer valuable insights into human cancer. Comparative genomic analyses reveal surprising molecular similarities, identifying potential new cancer biomarkers and therapeutic targets.

Keywords:

Array CGH Cancer models Deep-sequencing Exome-sequencing Genome-wide Medaka Microarray RNA-seq Xiphophorus Zebrafish

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Last Updated: Mar 16, 2026

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Generation of Zebrafish Larval Xenografts and Tumor Behavior Analysis

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Published on: June 19, 2021

Area of Science:

Comparative oncology
Genomics
Translational research

Background:

Zebrafish and medaka are increasingly utilized as experimental models for cancer research.
Advancements in genomic and transcriptomic analysis technologies enable comprehensive studies in these fish models.

Purpose of the Study:

To compare molecular features of tumors in zebrafish and medaka models with human tumors.
To identify novel biomarkers and therapeutic targets for human cancers based on fish model data.

Main Methods:

Whole genome, exome, and transcriptome analyses were performed on zebrafish and medaka tumor models.
Comparative analyses were conducted between the two fish models and with human tumor datasets.

Main Results:

A high degree of molecular comparability was found between fish and human tumors.
Novel molecular candidates, overlooked in human cancer studies, were identified in the fish models.

Conclusions:

Zebrafish and medaka tumor models are highly relevant for understanding human cancer.
These fish models provide a valuable resource for discovering new biomarkers and therapeutic strategies for cancer treatment.