Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

7.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
7.4K
Regulation of Angiogenesis and Blood Supply01:24

Regulation of Angiogenesis and Blood Supply

3.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.9K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.6K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.6K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.4K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.4K
Mechanism of Lamellipodia Formation01:31

Mechanism of Lamellipodia Formation

3.9K
Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Charging capacitors using diodes at different temperatures. I. Theory.

Physical review. E·2026
Same author

Charging capacitors using diodes at different temperatures. II. Numerical studies.

Physical review. E·2026
Same author

Power laws of natural swarms as fingerprints of an extended critical region.

Physical review. E·2024
Same author

Soliton approximation in continuum models of leader-follower behavior.

Physical review. E·2023
Same author

Charging capacitors from thermal fluctuations using diodes.

Physical review. E·2023
Same author

Mean-field theory of chaotic insect swarms.

Physical review. E·2023
Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026
Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026
Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026
Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026
Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026
Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Mar 16, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

10.2K

Soliton driven angiogenesis.

L L Bonilla1, M Carretero1, F Terragni1

  • 1Gregorio Millán Institute for Fluid Dynamics, Nanoscience and Industrial Mathematics and Department of Materials Science &Engineering, Universidad Carlos III de Madrid, Avenida de la Universidad 30, 28911 Leganés, Spain.

Scientific Reports
|August 10, 2016
PubMed
Summary
This summary is machine-generated.

Tumor-induced angiogenesis, the growth of blood vessels, is driven by a soliton. Analyzing this soliton offers a new way to control blood vessel growth, crucial for cancer therapy.

More Related Videos

2.5D Model for Ex Vivo Mechanical Characterization of Sprouting Angiogenesis in Living Tissue
10:00

2.5D Model for Ex Vivo Mechanical Characterization of Sprouting Angiogenesis in Living Tissue

Published on: February 28, 2025

923
Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.8K

Related Experiment Videos

Last Updated: Mar 16, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

10.2K
2.5D Model for Ex Vivo Mechanical Characterization of Sprouting Angiogenesis in Living Tissue
10:00

2.5D Model for Ex Vivo Mechanical Characterization of Sprouting Angiogenesis in Living Tissue

Published on: February 28, 2025

923
Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay
09:03

Author Spotlight: Investigating Angiogenesis and Vessel Permeability Through a Modified Matrix Gel Plug Assay

Published on: June 30, 2023

1.8K

Area of Science:

  • Biophysics
  • Mathematical Biology
  • Computational Biology

Background:

  • Angiogenesis is vital for normal tissue repair and organ growth.
  • Tumor growth can hijack angiogenesis, promoting cancer progression.
  • Existing mathematical models often lack detailed analysis, limiting therapeutic insights.

Purpose of the Study:

  • To analyze a stochastic model of tumor-induced angiogenesis.
  • To identify the driving mechanism behind vessel tip density advancement.
  • To explore methods for controlling angiogenesis via mathematical modeling.

Main Methods:

  • Developed a stochastic model incorporating vessel branching, elongation, and anastomosis.
  • Extracted a deterministic integro-partial differential equation for vessel tip density.
  • Analyzed the collective coordinates of the vessel tip density using soliton dynamics.

Main Results:

  • Identified a soliton, akin to the Korteweg-de Vries soliton, driving chemotactic advancement of vessel tips towards tumors.
  • The soliton's shape and velocity exhibit slow changes.
  • This analysis provides a deterministic description of angiogenesis dynamics.

Conclusions:

  • The soliton acts as the engine driving tumor-induced angiogenesis.
  • Understanding and analyzing these collective coordinates offers potential therapeutic strategies for controlling angiogenesis.
  • This work paves the way for developing novel anti-angiogenic therapies targeting the soliton mechanism.