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Updated: Mar 16, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Disrupted functional connectivity in adolescent obesity.

Laura Moreno-Lopez1, Oren Contreras-Rodriguez2, Carles Soriano-Mas3

  • 1Division of Anaesthesia, University of Cambridge, Cambridge, UK.

Neuroimage. Clinical
|August 10, 2016
PubMed
Summary
This summary is machine-generated.

Adolescent obesity is linked to altered brain connectivity, affecting reward sensitivity and cognitive control. These neuroadaptations highlight obesity as a complex brain disorder requiring targeted prevention strategies.

Keywords:
AdolescentsFunctional connectivityObesityResting statefMRI

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Area of Science:

  • Neuroscience
  • Adolescent Health
  • Obesity Research

Background:

  • Obesity is associated with brain alterations, specifically a hyperactive reward system and weakened cognitive control.
  • The presence of these brain changes in adolescents with excess weight remains under-investigated, particularly regarding global functional connectivity.

Purpose of the Study:

  • To investigate functional brain connectivity differences in adolescents with excess weight compared to normal-weight controls.
  • To characterize the extent of altered functional network integrity and its association with reward sensitivity in adolescent obesity.

Main Methods:

  • Functional connectivity was examined in 60 adolescents with excess weight and 55 normal-weight controls.
  • Brain regions with significant global connectivity differences between groups were identified.
  • The relationship between altered connectivity patterns and reward sensitivity was analyzed.

Main Results:

  • Adolescent obesity was associated with neuroadaptations in functional connectivity within key brain hubs: insula (interoception), middle temporal gyrus (emotional memory), and dorsolateral prefrontal cortex (cognitive control).
  • Reduced connectivity was observed between the insula and anterior cingulate cortex, and between the middle temporal gyrus and posterior cingulate cortex/cuneus/precuneus.
  • Increased connectivity was found between the middle temporal gyrus and the orbitofrontal cortex, and these networks correlated with reward sensitivity.

Conclusions:

  • Adolescent obesity is linked to disrupted functional connectivity in brain networks crucial for balancing reward, emotion, and cognitive control.
  • These findings support reconceptualizing obesity as a multi-layered brain disorder impacting motivation and control.
  • The study provides a biological basis for developing targeted prevention strategies for adolescent obesity.