Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

750
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
750
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

618
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
618
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

716
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
716
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

731
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
731
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

548
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
548
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

584
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
584

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

JAK Inhibition in <i>PNPT1</i>-Related Mitochondrial Interferonopathy: A Case Report and Review of Mitochondrial-Immune Crosstalk.

JIMD reports·2026
Same author

The clinical utility of functional testing in fibroblasts to diagnose primary mitochondrial disease.

medRxiv : the preprint server for health sciences·2026
Same author

A retrospective cross-sectional study on newborn screening and prevalence of disorders among UAE population.

Frontiers in pediatrics·2026
Same author

Efficacy and safety of pyrimidine nucleos(t)ide therapy in thymidine kinase 2 deficiency.

Brain communications·2026
Same author

Subacute Onset of Tremor, Ataxia, and Seizure-Like Episodes in a 7-Year-Old Boy.

Pediatrics in review·2026
Same author

A Case of Multiple Mitochondrial Dysfunctions Syndrome 1 and Review of the Literature.

American journal of medical genetics. Part A·2026

Related Experiment Video

Updated: Mar 16, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K

Mitochondrial Cardiomyopathies.

Ayman W El-Hattab1, Fernando Scaglia2

  • 1Division of Clinical Genetics and Metabolic Disorders, Department of Pediatrics, Tawam Hospital , Al-Ain , United Arab Emirates.

Frontiers in Cardiovascular Medicine
|August 10, 2016
PubMed
Summary
This summary is machine-generated.

Mitochondrial diseases, caused by mutations in mitochondrial or nuclear DNA, frequently affect the heart, leading to various cardiomyopathies. These conditions impair energy production, impacting high-energy organs like the heart.

Keywords:
Barth syndromeFriedreich ataxiadilated cardiomyopathyhistiocytoid cardiomyopathieshypertrophic cardiomyopathynon-compaction cardiomyopathyrestrictive cardiomyopathy

More Related Videos

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics
07:03

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics

Published on: August 23, 2024

1.6K
Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

37.9K

Related Experiment Videos

Last Updated: Mar 16, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.4K
Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics
07:03

Author Spotlight: Uncovering the Role of Mitochondrial Calcium Phosphate in Heart Failure and Bioenergetics

Published on: August 23, 2024

1.6K
Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
06:53

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry

Published on: November 23, 2011

37.9K

Area of Science:

  • Cell Biology
  • Genetics
  • Cardiology

Background:

  • Mitochondria, crucial for cellular energy, are controlled by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA).
  • Mitochondrial dysfunction arises from mutations in mtDNA or nDNA-related genes, impairing energy production in high-demand organs.
  • Cardiac muscle, with its high energy needs, is particularly susceptible to mitochondrial dysfunction, leading to cardiomyopathies.

Purpose of the Study:

  • To review the prevalence and spectrum of cardiac involvement in mitochondrial diseases.
  • To elucidate the genetic and molecular basis of mitochondrial cardiomyopathies.
  • To highlight the clinical significance of cardiomyopathy in pediatric mitochondrial disorders.

Main Methods:

  • Literature review of mitochondrial diseases and cardiac manifestations.
  • Analysis of genetic defects associated with mitochondrial cardiomyopathies.
  • Categorization of cardiomyopathy types observed in mitochondrial disorders.

Main Results:

  • Cardiomyopathy affects 20-40% of children with mitochondrial diseases, ranging from asymptomatic to severe heart failure.
  • Hypertrophic cardiomyopathy is most common, but dilated, restrictive, and other forms also occur.
  • Defects in electron transport chain, mtDNA maintenance, and coenzyme Q10 synthesis are frequently implicated.

Conclusions:

  • Cardiac involvement, particularly cardiomyopathy, is a frequent and significant complication of mitochondrial diseases.
  • Understanding the diverse genetic causes of mitochondrial cardiomyopathies is crucial for diagnosis and management.
  • Early recognition and characterization of cardiac issues are vital for improving outcomes in patients with mitochondrial disorders.