Core Outcomes for Colorectal Cancer Surgery: A Consensus Study.

Area of Science:

• Oncology
• Surgical Research
• Clinical Trials

Background:

• Colorectal cancer (CRC) poses a significant global health burden, with surgery being a primary treatment modality.
• Standardized outcome measurement in randomized controlled trials (RCTs) is crucial for comparing surgical interventions and minimizing bias.
• This study addresses the need for a unified approach to outcome assessment in CRC surgical research.

Framework:

• A systematic literature review and patient interviews identified potential outcomes for CRC surgery.
• Stakeholder input via Delphi surveys and consensus meetings refined these outcomes.
• A 12-domain core outcome set (COS) was established through robust consensus methodology.

Implementation:

• The COS development involved iterative feedback from patients and healthcare professionals across UK CRC centers.
• Systematic reviews identified 1,216 potential outcomes, narrowed down to 91 domains for initial survey.
• Consensus meetings, including international professionals and patients, finalized the 12-domain COS.

Implications:

• The developed COS includes perioperative, quality of life, and oncological outcomes relevant to CRC surgery.
• This standardized set is intended to facilitate cross-study comparisons and meta-analyses in CRC surgical trials.
• Validation of the COS in research practice is the next critical step for its widespread adoption.