Is there a time limit for systemic menopausal hormone therapy?

Area of Science:

• Reproductive Medicine
• Endocrinology
• Geriatrics

Background:

• Hormone therapy (HT) is used for menopausal symptoms.
• Decisions about HT duration are complex.
• Individualized risk-benefit assessment is crucial.

Purpose of the Study:

• To review evidence on extending hormone therapy.
• To provide a guide for shared decision-making regarding HT cessation.

Main Methods:

• Literature review of evidence for and against extending HT.
• Analysis of factors influencing HT decisions.

Main Results:

• Key factors include patient age, preferences, symptoms, quality of life, menopausal duration, hysterectomy status.
• Personalized risk factors (osteoporosis, cancer, cardiovascular events) are critical.
• Evidence supports individualized approaches rather than a one-size-fits-all strategy.

Conclusions:

• Stopping hormone therapy is a highly individualized decision.
• Shared decision-making between patient and clinician is essential.
• Consideration of comprehensive patient factors ensures optimal outcomes.