Comments on estimations of risks to translocation carriers

Two projects for estimation of risks to carriers of reciprocal translocations based on data from more than 1,100 families are compared. The 2 projects differ considerably with regard to the amount of information utilized in the data, the statistical methods used--either standard computer programs or methods specially developed for the data--and the relevance and variety of the obtained results. The comparison shows the strength of utilizing tailor-made statistical methods for extracting relevant information from available data in human genetics instead of statistical standard methods from general computer programs.