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Colonic Macrophages "Remote Control" Adipose Tissue Inflammation and Insulin Resistance
Subhra K Biswas1, Raffaella Bonecchi2
1Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research (A(∗)STAR), #04-06 Immunos, 8A Biomedical Grove, Singapore 138648, Singapore.
Cell Metabolism
|August 11, 2016
Abstract:
The early events linking diet-induced adipose tissue inflammation and insulin resistance remain poorly understood. In this issue of Cell Metabolism, Kawano et al. (2016) show that infiltration of colonic pro-inflammatory macrophages orchestrated by the intestinal CCL2/CCR2 axis kick-starts this process during high-fat-diet feeding.
